Systems Biology, Biomedical Mechanics, Neurosurgical Systems, Cardiovascular Systems, Simulation Modeling, Signal Analysis, Computational Fluid Dynamics (CFD)

Mathematical Model for Hemodynamic and Intracranial Windkessel MechanismThe understanding of intracranial system so that one can explain its related pathological condition such as hydrocephalus and traumatic brain injury (TBI) is still subtle. Especially, the cause of hydrocephalus which is known as the common birth defect is not well defined. Traditionally, hydrocephalus was described as imbalance between production and absorption process of cerebrospinal fluid (CSF). However, many recent observations show that the bulk flow theory can no longer explain the cause of hydrocephalus. Hence, the new concept of hydrocephalus has been deviated from the bulk flow theory and comes to focus on the pulsatile dynamic of intracranial system and abnormalities of intracranial Windkessel mechanism. Thus, the simulation via mathematical model based on Windkessel mechanism, which is one of the most useful tool to clarify the pulsatile dynamic within intracranial cavity is developed. The mathematical model is constructed based on the mechanical and fluid mechanics principles to predict the hemodynamics throughout major arterial system and intracranial space.